tert-Butyl 2-Amino-4-(4-methyl-1-piperazinyl)benzoate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-Amino-4-(4-methyl-piperazin-1-yl)-benzoic acid tert-butyl ester
Nonfluorochemicals, API&Intermediates
KUMI0F268
1034975-35-3
MFCD26384463

Rea
66735920

Reax
10656924
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
tert-Butyl 2-Amino-4-(4-methyl-1-piperazinyl)benzoate
C16H25N3O2
291.39
98%
White to Yellow Solid

5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
tert-Butyl 2-Amino-4-(4-methyl-1-piperazinyl)benzoate is a pharmaceutial intermediate that typically in the preparation of RXDX-101 and NMS-E628, an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.
Characterization of NMS-E628, a small molecule inhibitor of anaplastic lymphoma kinase with antitumor efficacy in ALK-dependent lymphoma and non-small cell lung cancer models. [1]
Enrectinib (RXDX-101), an oral pan-Trk, ROS1, and ALK inhibitor in patients with advanced solid tumors harboring gene rearrangements. [2]
ALK inhibitors in non-small cell lung cancer: The latest evidence and developments. [3]
References:
[1] E.Ardini, et al, Mol. Cancer Ther., 2009, 8(12 Suppl.), pp A244-A244.
[2] S.Siena, et al, Eur. J. Cancer, 2015, 51(3 Suppl.), pp S724-S725.
[3] I.Sullivan, et al, Ther. Adv. Med. Oncol., 2016, 8(1), pp 32-47.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P280,P305+P351+P338
2933399990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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