tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate is a heterocyclic intermediate that commonly used in the preparation of various pharmaceutically active substances. An example is empolyed to prepare LOXO-292 as a selective and potent RET kinase inhibitor for the treatment of RET fusion-positive and RET-mutant cancers alike.
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors. 
Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities for α4β2 neuronal nicotinic acetylcholine receptors. 
Selective RET kinase inhibition for patients with RET-altered cancers.