tert-Butyl 3-aminoazetidine-1-carboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-Boc-3-aminoazetidine, 3-Aminoazetidine-1-carboxylic acid tert-butyl ester
Nonfluorochemicals, API&Intermediates
KUMI0F307
193269-78-2
MFCD01861753
1516507
11118769
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
tert-Butyl 3-aminoazetidine-1-carboxylate
C8H16N2O2
172.23
≥98%
Colorless to Light yellow Liquid

5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
tert-Butyl 3-aminoazetidine-1-carboxylate (also known as 1-Boc-3-aminoazetidine) is commonly used as intermediate in the preparation of pharmaceutically active substances, such as GDC-9545 (RG6171), which is a selective estrogen receptor degrader (SERD) that is designed to bind to the estrogen receptor to limit its function.
Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8. [1] 
The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer. [2]
References:
[1] T.J.Jenkis, et al, J. Med. Chem., 2007, 50(3), pp 566-584.
[2] J.D.Joseph, et al, eLife, 2016, 5:e15828.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H314,H318
P280,P305+P351+P338
29339980
UN 2735 8/PG III

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