tert-Butyl 3-(cyanomethylidene)azetidine-1-carboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-Boc-3-(cyanomethylene)azetidine
Nonfluorochemicals, API&Intermediates
KUMI0F239
1153949-11-1
MFCD12761241
45789216
19197759
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
tert-Butyl 3-(cyanomethylidene)azetidine-1-carboxylate
C10H14N2O2
194.23
≥98%
White to Pale Yellow Solid
75-77°C
5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
tert-Butyl 3-(cyanomethylidene)azetidine-1-carboxylate (also named as 1-Boc-3-(cyanomethylene)azetidine) is commonly used as intermediate in the preparation of various pharmaceutically active substances, such as Itacitinib (also named as INCB39110, INCB039110), which is a potent and selective inhibitor of JAK1 tyrosine kinase inhibitor in the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis.
A randomized, double-blind, placebo-controlled, dose-escalation study of the safety and efficacy of INCB039110, an oral janus kinase 1 inhibitor, in patients with stable, chronic plaque psoriasis. [1]
An Efficient Synthesis of Baricitinib. [2]
References:
[1] R.Bissonnette, et al, J. Dermatolog. Treat., 2016, 27(4), pp 332-338.
[2] J.Xu, et al, J. Chem. Res., 2016, 40(4), pp 205-208.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H301+H311+H331,H315,H319
P261,P280,P301+P310+P330
2933998090
UN 3439 6.1/PG III

1. Product Specification
2. Safety Data Sheet
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