tert-Butyl 4,7-diazaspiro[2.5]octane-4-carboxylate is a heterocyclic intermediate that typically used in the preparation of RG7916 as a selective survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the treatment of spinal muscular atrophy (SMA).
Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs. 
Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA). 
 A.Poirier, et al, Pharmacol. Res. Perspect, 2018, 6(6):e00447.
 H.Ratni, et al, J. Med. Chem., 2019, 61(15), pp 6501-6517.
NONH for all modes of transport
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