tert-Butyl 4-(cyclopropylmethyl)piperazine-1-carboxylate (also named as N-Boc-4-(cyclopropylmethyl)piperazine) was used to prepare a class of imidazole-free histamine H(3) receptor antagonists. It is recently employed in the preparation of AG348 (PKM2 activator 1020) as a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists. 
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. 
 F.Zaragoza, et al, J. Med. Chem., 2004, 47(11), pp 2833-2838.
 W.Qi, et al, Nat. Med., 2017, 23(6), pp 753-762.
NONH for all modes of transport
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