tert-Butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-Boc-4-[methoxy(methyl)carbamoyl]piperidine
Nonfluorochemicals, API&Intermediates
KUMI0F258
139290-70-3
MFCD07368262
11065582
7034977
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
tert-Butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate
C13H24N2O4
272.34
≥98%
White to Off-white Solid
51-54°C
5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
tert-Butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate is a heterocyclic intermediate that commonly used in the preparation of various Pharmaceutically active substances, e.g.  ACP-196, a selective second-generation BTK inhibitor.
1,2,3,4-Tetrahydroquinoline-containing αVβ3 integrin antagonists with enhanced oral bioavailability. [1]
Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists. [2]
Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor. [3]
References:
[1] S.Ghosh, et al, Bioorg. Med. Chem. Lett., 2004, 14(23), pp 5837-5941.
[2] D.Mabire, et al, J. Med. Chem., 2005, 48(6), pp 2134-2153.
[3] J.Wu, et al, J. hematol. Oncol., 2016, 9, pp 21-24.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302

2933399990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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