Tetrahydro-4H-pyran-4-one

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-Oxotetrahydropyran, Oxan-4-one
Nonfluorochemicals, API&Intermediates
KUMI0F269
29943-42-8
MFCD00006581

Rea
121599

Reax
106463
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Tetrahydro-4H-pyran-4-one
C5H8O2
100.12
98%
Colorless to Slightly Pale Yellow Liquid
166-167°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
Tetrahydro-4H-pyran-4-one is a heterocyclic building block that commonly used organic synthses. One example is empolyed in the preparation of RXDX-101 and NMS-E628, an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.
Characterization of NMS-E628, a small molecule inhibitor of anaplastic lymphoma kinase with antitumor efficacy in ALK-dependent lymphoma and non-small cell lung cancer models. [1]
Enrectinib (RXDX-101), an oral pan-Trk, ROS1, and ALK inhibitor in patients with advanced solid tumors harboring gene rearrangements. [2]
ALK inhibitors in non-small cell lung cancer: The latest evidence and developments. [3]
References:
[1] E.Ardini, et al, Mol. Cancer Ther., 2009, 8(12 Suppl.), pp A244-A244.
[2] S.Siena, et al, Eur. J. Cancer, 2015, 51(3 Suppl.), pp S724-S725.
[3] I.Sullivan, et al, Ther. Adv. Med. Oncol., 2016, 8(1), pp 32-47.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H226

2932990090 
UN 1224 3/PG III

1. Product Specification
2. Safety Data Sheet
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