trans-4-Ethylpyrrolidine-3-carboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(3R,4R)-4-ethylpyrrolidine-3-carboxylic acid
Nonfluorochemicals, API&Intermediates
KUMI0F291
261896-33-7
 

Rea
10197754

Reax
15731142
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
trans-4-Ethylpyrrolidine-3-carboxylic acid
C7H13NO2
143.18
98%(99%ee)
White to Off-white Solid

5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
trans-4-Ethylpyrrolidine-3-carboxylic acid is a heterocyclic intermediate that typically used in the preparation of ABT-494 as a potent and selective JAK inhibitors in the treatment of Rheumatoid Arthritis and an Inadequate Response to Methotrexate.
Efficacy and Safety of ABT-494, a Selective JAK-1 Inhibitor, in a Phase IIb Study in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate. [1]
A Phase IIb Study of ABT-494, a Selective JAK-1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti-Tumor Necrosis Factor Therapy. [2]
References:
[1] M.C.Genovese, et al, Arthritis Rheumatol., 2016, 68(12), pp 2857-2866.
[2] J.M.Kremer, et al, Arthritis Rheumatol., 2016, 68(12), pp 2867-2877.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
29337900900
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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