Triethyl orthoacetate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1,1,1-Triethoxyethane, Orthoacetic acid triethyl ester
Non-Fluorochemicals, API & Intermediates
KUMI0F1019
78-39-7

PubChem ID

Reax
MFCD00009223

PubChem ID
66221
506201
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Triethyl orthoacetate
C8H18O3
162.23
≥98%
Colorless to Pale Yellow Liquid
142-145°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
Triethyl orthoacetate (also known as 1,1,1-Triethoxyethane, Orthoacetic acid triethyl ester) is typically used as pharmaceutial and water scavenger, and also employed in organic synthesis to introduce the acetate group into an alcohol.  for example, it is used as a starting material in the synthesis  of Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist.
Efficient esterification of carboxylic acids and phosphonic acids with trialkyl orthoacetate in ionic liquid. [1]
Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. [2]
Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1. [3]
Annulated 3-Amino-4-Imino-Pyrimidines: Their Utility as Useful Precursors for the Synthesis of Fused Heterocycles. [4]
References:
[1] T.Yoshino, et al, Tetrahedron, 2006, 62(6), pp 1309-1317.
[2] L.Barfacker, et al, ChemMedChem, 2012, 7(8), pp 1385-1403.
[3] L.Amezit, et al, J. Biol. Chem., 2015, 290(36), pp 21876-21889.
[4] A.S.Shawali, et al, Curr. Org. Synth., 2015, 12(4), pp 391-430.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H226
P210
29333990
UN 3272 3/PG III

1. Product Specification
2. Safety Data Sheet
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