N-methyl-N-trimethylsilylacetamide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-Methyl-N-TMS-acetamide, TMA , MSA
Non-Fluorochemicals, Trimethylsilylating agents
KUMI0F51
7449-74-3
MFCD00040758
81953
506975
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
N-methyl-N-trimethylsilylacetamide
C6H15NOSi
145.28
≥98.0%(GC)
Colorless to Slightly Pale Yellow Liquid
159-161ºC
5g,10g,20g,50g,100g,500g and 1kg
Store at 2~8°C temperature
N-methyl-N-trimethylsilylacetamide is a powerful silylating reagent for polar compounds and trimethylsilylating reagent for protection of the hydroxyl groups, including 1,2‐ and 1,3‐Diols.
Protection for the Hydroxyl Group, Including 1,2‐ and 1,3‐Diols. [1]
Two competitive routes and the mechanism of trans-silylation of N-trimethylsilyl-N-methylacetamide: Quantum chemical and FTIR study. [2]
Reaction of transsilylation of N-methyl-N-trimethylsilylacetamide with silanes ClCH2SiR1R2Cl. [3]
References:
[1] P.G.M.Wuts, et al,  Greene’s Protective Groups in Organic Synthesis, 5th ed., New Jersey, 2014, Chap. 2, 17.
[2] N.F.Lazareva, et al, J. Organomet. Chem., 2016, 824, pp 48-60.
[3] N.F.Lazareva, et al, Russian J. General Chem., 2017, 87(8), pp 1721-1726.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H226,H315,H319,H335
P210,P261,P303+P361+P353,P305+P351+P338,P405,P501
2931900090
UN 1993 3/PG III

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