Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
(Trimethyl)trifluoromethylsilane, Ruppert’s Reagent, TFMTMS,CF3TMS
Trifluoromethylating Reagents,Difluorocarbene Precursors 
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Boiling  Point
Flash Point
≥99.0% (GC)
Colorless to Light yellow Liquid
-17ºC(closed cup)
5g,10g,50g,100g,500g,1kg and 25kg
Store locked-up, in a cool, well-ventilated place
1.Nucleophilic Trifluoromethylation
1) Aldehydes and Ketones: 
Synthetic methods and reactions. 141. Fluoride-induced trifluoromethylation of carbonyl compounds with trifluoromethyltrimethylsilane (TMS-CF3). A trifluoromethide equivalent. [1]
A Weinreb amide approach to the synthesis of trifluoromethylketones. [2]
2) Enones:
Trans enones react with CF3-TMS in the presence of a catalytic amount of cesium fluoride to give trifluoromethylated allylic alcohols. [3]
3) Esters:
Esters react with CF3-TMS in the presence of a stoichiometric amount of F- to give the corresponding trifluoromethylketones. [4]
4) Aromatics:
The transient trifluoromethylcopper species is generated in situ from CF3-TMS in the presence of cuprous iodide and potassium fluoride; reaction with aryl iodide gives trifluoromethylated aryl compounds. [5]
5) Alkyl Iodides:
Silver-mediated fluorination of alkyl iodides with TMSCF3 as the fluorinating agent. [6]
6) Convenient Source of CF2=CF2:
TMSCF3 as a Convenient Source of CF2=CF2 for Pentafluoroethylation, (Aryloxy)tetrafluoroethylation, and Tetrafluoroethylation. [7]
7) Miscellaneous Trifluoromethylations of Carbohydrates:
Trifluoromethylation of 3-oxo-glucose proceeds with CF3-TMS and gives the L-allo isomer in 100% selectivity, although CF3MgBr gives the L-allo and D-gluco isomers in the ratio of 75:25, respectively. [8]
8) Stereoselective Trifluoromethylation of Secondary Propargyl Sulfonates:
Copper-Catalyzed Highly Stereoselective Trifluoromethylation and Difluoroalkylation of Secondary Propargyl Sulfonates. [9]
2.Difluorocarbene Precursor
Synthesis of gem-difluorinated cyclopropanes and cyclopropenes: trifluoromethyltrimethylsilane as a difluorocarbene source. [10]
2.Pentafluoroethylation Precursor
From C1 to C2: TMSCF3 as an Efficient Precursor for Pentafluoroethylation. [11]
[1] G.K.S. Prakash, et al, J.Am.Chem. Soc, 111, 393(1989).
[2] D.M.Rudzinski, et al, Chem.Commun.2012,48,9610.
[3] R.P. Singh, et al, Org. Lett. 1. 1047(1999).
[4] J.Wiedemann, et al, Angew. Chem. Int.Ed.,37.820(1998).
[5] T.Fuchikami, et al, JP 1991-218325.
[6] L.Wang, et al, Org. Chem. Front., 2017, Advance Article.
[7] L. Li, et al, Angew. Chem. Int. Ed., 2017, 56, pp 1-6.
[8] S.Lavaire, et al, Tetrahedron Asymmetry, 9,213(1998).
[9] X.Gao, et al, Angew. Chem. Int. Ed. Engl., 2018, 57(12), pp 3187-3191.
[10] F.Wang, et al, Angew.Chem. Int.50.7153(2011).
[11] Q.Xie, et al, Angew. Chem. Int. Ed. Engl., 2018.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
Legal Information
UN 1993 BF 3/PG II

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