Synthetic methods and reactions. 141. Fluoride-induced trifluoromethylation of carbonyl compounds with trifluoromethyltrimethylsilane (TMS-CF3). A trifluoromethide equivalent.
A Weinreb amide approach to the synthesis of trifluoromethylketones. 
Trans enones react with CF3-TMS in the presence of a catalytic amount of cesium fluoride to give trifluoromethylated allylic alcohols. 
Esters react with CF3-TMS in the presence of a stoichiometric amount of F- to give the corresponding trifluoromethylketones.
The transient trifluoromethylcopper species is generated in situ from CF3-TMS in the presence of cuprous iodide and potassium fluoride; reaction with aryl iodide gives trifluoromethylated aryl compounds. 
5) Alkyl Iodides:
Silver-mediated fluorination of alkyl iodides with TMSCF3 as the fluorinating agent.
6) Convenient Source of CF2=CF2:
TMSCF3 as a Convenient Source of CF2=CF2 for Pentafluoroethylation, (Aryloxy)tetrafluoroethylation, and Tetrafluoroethylation. 
7) Miscellaneous Trifluoromethylations of Carbohydrates:
Trifluoromethylation of 3-oxo-glucose proceeds with CF3-TMS and gives the L-allo isomer in 100% selectivity, although CF3MgBr gives the L-allo and D-gluco isomers in the ratio of 75:25, respectively. 
8) Stereoselective Trifluoromethylation of Secondary Propargyl Sulfonates:
Copper-Catalyzed Highly Stereoselective Trifluoromethylation and Difluoroalkylation of Secondary Propargyl Sulfonates. 
Synthesis of gem-difluorinated cyclopropanes and cyclopropenes: trifluoromethyltrimethylsilane as a difluorocarbene source. 
From C1 to C2: TMSCF3 as an Efficient Precursor for Pentafluoroethylation. 
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