1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-[2-(2,2,2-trifluoroethoxy) phenoxy] ethyl methanesulfonate
Trifluoromethyl Building Blocks, API & Intermediates
KUMI3F42
160969-03-9
MFCD16038209
10519307
7823882
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
C11H13F3O5S
314.28
≥99%(HPLC)
Off-white to Yellow Solid
52-56°C
5g,10g,25g,50g,100g,250g and 500g
Store at room temperature
1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene is a useful trifluoromethylated building block and production intermediate for the synthesis of Silodosin (S465000) which is an alpha.1-adrenoceptor antagonist ,used for the treatment of benign prostatic hypertophy.
N-Arylpiperazinyl-N-propylamino Derivatives of Heteroaryl Amides as Functional Uroselective α1-Adrenoceptor Antagonists. [1]
Enantioselective synthesis of (−)-(R) Silodosin by ultrasound-assisted diastereomeric crystallization. [2]
Synthesis of Silodosin by Copper‐Catalysed C–C Arylation. [3]
References:
[1] T.R.Elworthy, et al, J. Med. Chem., 1997, 40(17), pp 2674-2687.
[2] I.J.Barve, et al, Tetrahedron, 2013, 69(13), pp 2834-2843.
[3] F.Calogero, et al, Eur. J. Org. Chem., 2015, 2015(27), pp 6011-6016.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P264,P280
2909.30.6000
NONH for all modes of transport

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