1-hydroxymethyl-1-(trifluoromethyl)cyclopropane

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
 (1-(trifluoromethyl)cyclopropyl)methanol
Trifluoromethyl Building Blocks
KUMI3F77
371917-17-8
MFCD16990760
50990661
8830169
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Boiling Point
Packaging
Storage
1-hydroxymethyl-1-(trifluoromethyl)cyclopropane
C5H7F3O
140.11
≥98.0%(GC)
Colorless to Yellow Liquid
126-128°C
1g,5g,10g,25g,50g,100g and 500g
Store at room temperature
1-hydroxymethyl-1-(trifluoromethyl)cyclopropane is a useful trifluoromethylated azetidine building block for the synthesis of various pharmaceutical compounds, such as GPR119 Agonists and SGLT2 Inhibitors, etc..
Routes from 1,1-cycloalkanedicarboxylic acids to geminal bis(polyfluoromethyl) substituted carbocycles. [1]
Efficient synthesis of 2,6-disubstituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters. [2]
References:
[1] A.Wolniewicz, et al, J. F. Chem., 2001, 109(2), pp 95-102.
[2] D.E.Murphy, et al, Tetrahedron Lett., 2008, 49(5), pp 811-815.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H320
P280,P305+P351+P338

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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