1-hydroxymethyl-1-(trifluoromethyl)cyclopropane is a useful trifluoromethylated azetidine building block for the synthesis of various pharmaceutical compounds, such as GPR119 Agonists and SGLT2 Inhibitors, etc..
Routes from 1,1-cycloalkanedicarboxylic acids to geminal bis(polyfluoromethyl) substituted carbocycles.
Efficient synthesis of 2,6-disubstituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters.
 A.Wolniewicz, et al, J. F. Chem., 2001, 109(2), pp 95-102.
 D.E.Murphy, et al, Tetrahedron Lett., 2008, 49(5), pp 811-815.