1-trifluoromethyl-1-cyclobutylcarboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(1-trifluoromethyl)cyclobutanecarboxylic acid
Trifluoromethyl Building Blocks
KUMI3F74
277756-45-3
MFCD03425197
2782838
8544724
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Boiling Point
Packaging
Storage
1-trifluoromethyl-1-cyclobutylcarboxylic acid
C6H7F3O2
168.12
≥98.0%(GC)
Colorless Clear Liquid
74-76°C/13 mmHg
1g,5g,10g,25g,50g,100g and 500g
Store at room temperature
1-trifluoromethyl-1-cyclobutylcarboxylic acid is a useful trifluoromethylated cyclobutane building block for synthesis of various pharmaceutical compounds, e.g. bombesin receptor, subtype-3 modulators, Flaviviridae viruses inhibitors, GPR119 agonists and SGLT2 inhibitors, etc..
Selective reactions of 1,1-cycloalkanedicarboxylic acids with SF4. a route to 1,1-bis(trifluoromethyl)cycloalkanes, 1-fluoroformyl-1-(trifluoromethyl) cycloalkanes and 1-(trifluoromethyl)-1-cycloalkanecarboxylic acids. [1]
Solid-phase synthesis of aryl, heteroaryl, and sterically hindered alkyl amines using the Curtius rearrangement. [2]
Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1, 1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E. [3]
Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection. [4]
Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome. [5]
Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain. [6]
References:
[1] W.Dmowski, et al, J. F. Chem., 2002, 102(1-2), pp 141-146.
[2] S.Sunami, et al, Tetrahedron, 2009, 65(3), pp 638-643.
[3] M.W.Rowbottom, et al, J. Med. Chem., 2012, 55(3), pp 1082-1105.
[4] S.E.Lazerwith, et al, J. Med. Chem. 2014, 57(5), pp 1893-1901.
[5] Y.Ren, et al, J. Med. Chem., 2017, 60(3), pp 972-986.
[6] S.Han, et al, ACS Med. Chem. Lett., 2017, 8(12), pp 1309-1313.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H301,H319
P301+P310,P305+P351+P338
2916.20.5000
UN 2810 6.1/PG III

1. Product Specification
2. Safety Data Sheet
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