2,8-bis(trifluoromethyl)quinolin-4-ol

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,8-Bis(trifluoromethyl)-4-hydroxyquinoline
Trifluoromethyl Building Blocks
KUMI6F15
35853-41-9
MFCD00075091
736140
1483406
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2,8-bis(trifluoromethyl)quinolin-4-ol
C11H5F6NO
281.15
≥99%
White to Off-white Solid
129-131°C
5g,10g,25g,50g,100g,250g and 500g
Store at room temperature
2,8-bis(trifluoromethyl)quinolin-4-ol is a trifluoromethlated intermediate for the preparation of some pharmaceutical active substances with antibacterial activities, such as anti-Zika Virus(ZIKV).
Synthesis of novel substituted / unsubstituted- (2,8-bis-trifluoromethyl-quinolin-4-yloxy)-acetic acid: Derivatives of cephalosporin and their antibacterial activity. [1]
2,8-bis(trifluoromethyl)quinoline analogs show improved anti-Zika virus activity, compared to mefloquine. [2]
References:
[1] S.K.Singh, et al, Indian J. Chem. (Section B), 2006,  45(7), pp 1734-1739.
[2] G.Barbosa-Lima, et al, Eur. J. Med. Chem., 2017, 127, pp 334-340.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P271,P280
2933499090
NONH for all  modes of transport

1. Product Specification
2. Safety Data Sheet
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