2-amino-4-(trifluoromethyl)pyrimidine is an important trifluoromethylated heterocycle building block for the synthesis of various pharmaceutical products, e.g. inhibitors of dipeptidyl peptidase IV,RAF1 kinase inhibitors and Kinesin spindle protein inhibitors, etc..
Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABAAα2/α3 binding site agonists for the treatment of anxiety disorders. 
From lead to preclinical candidate: Optimization of β-homophenylalanine based inhibitors of dipeptidyl peptidase IV. 
Identification of NVP-BKM120 as a potent, selective, orally bioavailable class i PI3 kinase inhibitor for treating cancer. 
Novel quinolinylaminoisoquinoline bioisosteres of sorafenib as selective RAF1 kinase inhibitors: Design, synthesis, and antiproliferative activity against melanoma cell line. 
Kinesin spindle protein inhibitors with diaryl amine scaffolds: Crystal packing analysis for improved aqueous solubility. 
Molecular Oxygen-Mediated Minisci-Type Radical Alkylation of Heteroarenes with Boronic Acids. 
 S.C.Goodacre, et al, J. Med. Chem., 2006, 49(1), pp 35-38.