2-amino-4-(trifluoromethyl)pyrimidine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-(trifluoromethyl)pyrimidin-2-ylamine
Trifluoromethyl Building Blocks
KUMI3F86
16075-42-6
MFCD00828624
595915
909556
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2-amino-4-(trifluoromethyl)pyrimidine
C5H4F3N3
163.10
≥98.0%
Yellow Solid
174-178°C
1g,5g,10g,25g,50g,100g and 500g
Store at room temperature
2-amino-4-(trifluoromethyl)pyrimidine is an important trifluoromethylated heterocycle building block for the synthesis of various pharmaceutical products, e.g. inhibitors of dipeptidyl peptidase IV,RAF1 kinase inhibitors and Kinesin spindle protein inhibitors, etc..
Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABAAα2/α3 binding site agonists for the treatment of anxiety disorders. [1]
From lead to preclinical candidate: Optimization of β-homophenylalanine based inhibitors of dipeptidyl peptidase IV. [2]
Identification of NVP-BKM120 as a potent, selective, orally bioavailable class i PI3 kinase inhibitor for treating cancer. [3]
Novel quinolinylaminoisoquinoline bioisosteres of sorafenib as selective RAF1 kinase inhibitors: Design, synthesis, and antiproliferative activity against melanoma cell line. [4]
Kinesin spindle protein inhibitors with diaryl amine scaffolds: Crystal packing analysis for improved aqueous solubility. [5]
Molecular Oxygen-Mediated Minisci-Type Radical Alkylation of Heteroarenes with Boronic Acids. [6]
References:
[1] S.C.Goodacre, et al, J. Med. Chem., 2006, 49(1), pp 35-38.
[2] S.Nordhoff, et al, Bioorg. Med. Chem. Lett., 2009, 19(16), pp 4818-4823.
[3] M.T.Burger, et al, Med. Chem. Lett., 2011, 2(10), pp 774-779.
[4] H.J.Cho, et al, Chem. Pharm. Bull.(Tokyo), 2013, 61(7), pp 747-756.
[5] T.Takeuchi, et al. Med. Chem. Lett., 2014, 5(5), pp 566-571.
[6] L.Zhang, et al, Org. Lett., 2017, 19(24), pp 6594-6597.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H300,H319,H334,H400
P261,P264,P273,P301+P310,P305+P351+P338,P342+P311
2933.59.9500
UN 2811 6.1/PG III

1. Product Specification
2. Safety Data Sheet
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