2-Amino-5-bromo-4-(trifluoromethyl)pyridine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-bromo-4-(trifluoromethyl) pyridin-2-amine
Trifluoromethyl Building Blocks
KUMI3F154
944401-56-3
MFCD09864896
20525383
15519034
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2-Amino-5-bromo-4-(trifluoromethyl)pyridine
C6H4BrF3N2
241.01
≥95%
White to Orange Solid
66-75°C
5g,10g,25g,50g and 100g
Store at room temperature
2-Amino-5-bromo-4-(trifluoromethyl)pyridine is an useful building block for the synthesis of various pharmaceutical compounds, e.g. Imidazopyridine inhibitors of PI3 kinases,which is a family of lipid kinases mediating numerous cell processes such as proliferation, migration and differentiation.
An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]. [1]
Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K. [2]
Discovery of 2-(2-aminopyrimidin-5-yl)-4-morpholino-N-(pyridin-3-yl)quinazolin-7-amines as novel PI3K/mTOR inhibitors and anticancer agents. [3]
References:
[1] D.Zhang, et al, Chem. Commun., 2012, 48(23), pp 2909-2911.
[2] S.Pecchi, et al, Bioorg. Med. Chem. Lett., 2013, 23(16), pp 4652-4656.
[3] W.Peng, et al, Eur. J. Med. Chem., 2016, 108, pp 644-652.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H319
P305+P351+P338
2933399990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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