2-Amino-5-bromo-4-(trifluoromethyl)pyridine is an useful building block for the synthesis of various pharmaceutical compounds, e.g. Imidazopyridine inhibitors of PI3 kinases,which is a family of lipid kinases mediating numerous cell processes such as proliferation, migration and differentiation.
An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]. 
Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K. 
Discovery of 2-(2-aminopyrimidin-5-yl)-4-morpholino-N-(pyridin-3-yl)quinazolin-7-amines as novel PI3K/mTOR inhibitors and anticancer agents. 
 D.Zhang, et al, Chem. Commun., 2012, 48(23), pp 2909-2911.