2-chloro-4-trifluoromethylpyrimidine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-chloranyl-4-(trifluoromethyl)pyrimidine
Trifluoromethyl Building Blocks
KUMI3F89
33034-67-2
MFCD00115111
2773912
957607
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
2-chloro-4-trifluoromethylpyrimidine
C5H2ClF3N2
182.53
≥98.0%(GC)
Colorless to Yellow Liquid
60°C/15 mmHg
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at room temperature
2-chloro-4-trifluoromethylpyrimidine is a useful trifluoromethylated pyrimidine building block for the synthesis of various pharmaceutical compounds, such as reversible inhibitors of cysteine proteases, inhibitors of dipeptidyl peptidase IV(DPP-4) and Modulators of TRPV1, etc.. It may be employed to investigate the effect of chemical substitutions on the interfacial interactions of pyrimidines with the phospholipid-mimic immobilized-artificial-membrane (IAM) chromatographic stationary phase.
Complex retention behavior of pyrimidines on biomembrane-mimic immobilized-artificial-membrane phase. [1]
From lead to preclinical candidate: Optimization of β-homophenylalanine based inhibitors of dipeptidyl peptidase IV. [2]
A novel class of antihyperlipidemic agents with low density lipoprotein receptor up-regulation via the adaptor protein autosomal recessive hypercholesterolemia. [3]
Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. [4]
Silver catalysed decarboxylative alkylation and acylation of pyrimidines in aqueous media. [5]
Minisci alkylations of electron-deficient pyrimidines with alkyl carboxylic acids. [6]
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists. [7]
Synthesis, photoluminescence and electroluminescence of one iridium complex with 2-(2,4-difluorophenyl)-4-(trifluoromethyl)pyrimidine and tetraphenylimidodiphosphinate ligands. [8]
References:
[1] H.B.Luo, et al, J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2007, 853(1-2), PP 114-122.
[2] S.Nordhoff, et al, Bioorg. Med. Chem. Lett., 2009, 19(16), pp 4818-4823.
[3] S.Asano, et al, J. Med. Chem., 2010, 53(8), pp 3284-3295.
[4] M.S.Engelstoft, et al, Br. J. Pharmacol., 2014, 171(24), pp 5774-5789.
[5] W.P.Mai, et al, Org. Biomol. Chem., 2015, 13(9), pp 2750-2755.
[6] D.G.M. Shore, et al, Tetrahedron Lett., 2015, 56(27), pp 4063-4066.
[7] H.Zhang, et al, Bioorg. Med. Chem. Lett., 2015, 25(6), pp 1196-1205.
[8] Y.H.Zhou, et al, J. Organomet. Chem., 2017, 848(15), pp 226-231.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H226,H315,H319,H335
P261,P305+P351+P338
2933.59.9500
UN 1993C 3/PG III

1. Product Specification
2. Safety Data Sheet
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