2-chloro-4-trifluoromethylpyrimidine is a useful trifluoromethylated pyrimidine building block for the synthesis of various pharmaceutical compounds, such as reversible inhibitors of cysteine proteases, inhibitors of dipeptidyl peptidase IV(DPP-4) and Modulators of TRPV1, etc.. It may be employed to investigate the effect of chemical substitutions on the interfacial interactions of pyrimidines with the phospholipid-mimic immobilized-artificial-membrane (IAM) chromatographic stationary phase.
Complex retention behavior of pyrimidines on biomembrane-mimic immobilized-artificial-membrane phase. 
From lead to preclinical candidate: Optimization of β-homophenylalanine based inhibitors of dipeptidyl peptidase IV. 
A novel class of antihyperlipidemic agents with low density lipoprotein receptor up-regulation via the adaptor protein autosomal recessive hypercholesterolemia. 
Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. 
Silver catalysed decarboxylative alkylation and acylation of pyrimidines in aqueous media. 
Minisci alkylations of electron-deficient pyrimidines with alkyl carboxylic acids. 
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists. 
Synthesis, photoluminescence and electroluminescence of one iridium complex with 2-(2,4-difluorophenyl)-4-(trifluoromethyl)pyrimidine and tetraphenylimidodiphosphinate ligands. 
 H.B.Luo, et al, J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2007, 853(1-2), PP 114-122.