3,3,3-trifluoro-2,2-dimethylpropanoic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3,3,3-tris(fluoranyl)-2,2-dimethyl-propanoic acid
Trifluoromethyl Building Blocks
KUMI3F81
889940-13-0
MFCD08445819
19867367
18770059
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3,3,3-trifluoro-2,2-dimethylpropanoic acid
C5H7F3O2
156.10
≥98.0%(GC)
White to Tan Solid
66-71°C
1g,5g,10g,25g,50g,100g and 500g
Store at room temperature
3,3,3-trifluoro-2,2-dimethylpropanoic acid is a useful trifluoromethylated building block for the synthesis of various pharmaceutically active compounds, such as beta-secretase modulators, ion-channel ligands, GPR119 agonists, JAK and SYK inhibitors, SGC stimulators,dual inhibitors of neutrophil elastase and proteinase 3 and inhibitors of the microsomal prostaglandin E2 synthase-1, etc..
Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists. [1]
Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1, 1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP- 324 96), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E. [2]
Discovery of pyrroloaminopyrazoles as novel PAK inhibitors. [3]
A concise one-pot synthesis of trifluoromethyl-containing 2,6-disubstituted 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydronaphthyridines. [4]
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. [5]
Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection. [6]
Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3. [7]
Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2. [8]
Near-Infrared Fluorescence of Silicon Phthalocyanine Carboxylate Esters. [9]
References:
[1] C.M.Chu, et al, Org. Biomol. Chem., 2008, 6(18), pp 3399-3407.
[2] M.W.Rowbottom, et al, J. Med. Chem., 2012, 55(3), pp 1082-1105.
[3] C.Guo, et al, J. Med. Chem., 2012, 55(10), pp 4728-4739.
[4] R.J.Johnson, et al, Org. Biomol. Chem., 2013, 11(8), pp 1358-1366.
[5] P.Furet, et al, Bioorg. Med. Chem. Lett., 2013, 23(13), pp 3741-3748.
[6] S.E.Lazerwith, et al, J. Med. Chem., 2014, 57(5), pp 1897-1901.
[7] T.L.Hwang, et al, Bioorg. Med. Chem., 2015, 23(5), pp 1123-1134.
[8] L.J.Farmer, et al, Med. Chem. Lett., 2017, 8(2), pp 256-260.
[9] A.K.Pal, et al, Sci. Rep., 2017, 7(1), art. no. 12282.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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