3,3,3-trifluoro-2-methylpropanoic acid is a useful trifluoromethylated building block for the synthesis of various pharmaceutically or optically active compounds, such as RIPK 1(receptor interacting protein kinase 1) inhibitors and some antibacterial agents, etc..
Studies on the preparation of 2-(trifluoromethyl)acrylic acid and its esters from 3,3,3-trifluoropropene via hydrocarbonylation reactions.
Lipase mediated preparation of the enantiomers of 3,3,3-trifluoro-2- methylpropanoic acid.
Convenient synthesis of fluorinated alkanes and cycloalkanes by hydrogenation of perfluoroalkylalkenes under ultrasound irradiation.
Catalytic asymmetric hydrogenation of α-CF3- or β-CF3-Substituted acrylic acids using Rhodium(I) complexes with a combination of chiral and achiral ligands.
Direct Catalytic Asymmetric Mannich-Type Reaction of α- And β-Fluorinated Amides.
Synthesis of (R)- and (S)-α-trifluoromethyl propanoic acids via asymmetric hydrogenation followed by salt resolution.
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