3,3,3-trifluoro-2-methylpropanoic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(2RS)-3,3,3-trifluoro-2-methylpropanoic acid
Trifluoromethyl Building Blocks
KUMI3F79
381-97-5
MFCD19228247
11320987
1761627
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Boiling Point
Packaging
Storage
3,3,3-trifluoro-2-methylpropanoic acid
C4H5F3O2
142.08
≥98.0%(HPLC)
Colorless to Light-yellow Liquid
80°C/20 mmHg
1g,5g,10g,25g,50g,100g and 500g
Store at room temperature
3,3,3-trifluoro-2-methylpropanoic acid is a useful trifluoromethylated building block for the synthesis of various pharmaceutically or optically active compounds, such as RIPK 1(receptor interacting protein kinase 1) inhibitors and some antibacterial agents, etc..
Studies on the preparation of 2-(trifluoromethyl)acrylic acid and its esters from 3,3,3-trifluoropropene via hydrocarbonylation reactions. [1]
Lipase mediated preparation of the enantiomers of 3,3,3-trifluoro-2- methylpropanoic acid. [2]
Convenient synthesis of fluorinated alkanes and cycloalkanes by hydrogenation of perfluoroalkylalkenes under ultrasound irradiation. [3]
Catalytic asymmetric hydrogenation of α-CF3- or β-CF3-Substituted acrylic acids using Rhodium(I) complexes with a combination of chiral and achiral ligands. [4]
Direct Catalytic Asymmetric Mannich-Type Reaction of α- And β-Fluorinated Amides. [5]
Synthesis of (R)- and (S)-α-trifluoromethyl propanoic acids via asymmetric hydrogenation followed by salt resolution. [6]
References:
[1] C.Botteghi, et al, J. F. Chem., 1997, 83(1), pp 67-71.
[2] P.Beier, et al, Tetrahedron Asymmetry, 2004, 15(16), pp 2447-2449.
[3] Y.Carcenac, et al, J. F. Chem., 2005, 126(9-10), pp 1347-1355.
[4] K.Dong, et al, Angew. Chem. Int. Ed., 2013, 52(52), pp 14191-14195.
[5] L.Brewitz, et al, J. Am. Chem. Soc., 2015, 137(50), pp 15929-15939.
[6] M.Z.Chen, et al, Tetrahedron Asymmetry, 2016, 27(17-18), pp 882-887.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H314
P280,P305+P351+P338,P310

UN 3265 8/PG III

1. Product Specification
2. Safety Data Sheet
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