3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole
Trifluoromethyl Building Blocks
KUMI3F46
641571-11-1
MFCD11846236
253660623
11280392
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
C11H10F3N3
241.22
≥98.0%(GC)(T)
Off-white to Beige Solid
124-126°C
5g,10g,50g,100g,500g and1kg
Store at 2-8°C(recommended)
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is an intermediate in the preparation of Nilotinib, which is is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. This drug was developed by Novartis and is sold under the trade name Tasigna.
Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II. [1]
Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations. [2]
References:
[1] G. Zhang, et al, Bioorg. Med. Chem. Lett., 2009, 19, pp6691-6695.
[2] M.A.Seeliger, etal, Cancer Res., 2009, 69(6), pp2384-2392.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H301,H318
P280,P301+P310,P305+P351+P338
2933.29.4300
UN 2811 6.1/PG III

1. Product Specification
2. Safety Data Sheet
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