3-chloro-6-trifluoromethyl-pyridazine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-chloranyl-6-(trifluoromethyl)pyridazine
Trifluoromethyl Building Blocks
KUMI3F85
258506-68-2
MFCD08275188
28242526
5332446
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-chloro-6-trifluoromethyl-pyridazine
C5H2ClF3N2
182.53
≥98.0%(GC)
White to Light Brown Solid
94-95°C
1g,5g,10g,25g,50g,100g and 500g
Store at room temperature
3-chloro-6-trifluoromethyl-pyridazine is an important trifluoromethylated heterocycle building block for the synthesis of various pharmaceutical products, e.g. Therapeutic agents for diabetes, Fast dissociating dopamine 2 receptor antagonists, NPY Y5 receptor antagonists, GlyT1 inhibitors and ATR kinase inhibitors, etc..
Concise synthesis of ω-fluoroalkylated ketoesters. A building block for the synthesis of six-, seven-, and eight-membered fluoroalkyl substituted 1,2-diaza-3-one heterocycles. [1]
Selective GlyT1 inhibitors: Discovery of [4-(3-fluoro-5- trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2, 2-trifluoro-1-methyl ethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia. [2]
Exploration of a new series of CCR5 antagonists: Multi-dimensional optimization of a sub-series containing N-substituted pyrazoles. [3]
Copper-mediated trifluoromethylation of heteroaromatic compounds by trifluoromethyl sulfonium salts. [4]
Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. [5]
Enantioselective synthesis of BMS-911278: a triple reuptake inhibitor. [6]
Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain. [7]
References:
[1] W.wan, et al, Tetrahedron, 2009, 65(21), pp 4212-4219.
[2] E.Pinard, et al, J. Med. Chem., 2010, 53(12), pp 4603-4614.
[3] R.C.Lemoine, et al, Bioorg. Med. Chem. Lett., 2010, 20(16), pp 4753-4756.
[4] C.Zhang, et al, Angew. Chem. Int. Ed., 2011, 50(8), pp 1896-1900.
[5] A.M.Thompson, et al, J. Med. Chem., 2016, 59(6), pp 2530-2550.
[6] J.Li, et al, Tetrahedron Asymmetry, 2017, 28(1), pp 196-202.
[7] N.Tsuno, et al, Bioorg. Med. Chem., 2017, 25(7), pp 2177-2190.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H301,H315,H319
P301+P310,P305+P351+P338
2933.99.9701
UN 2811 6.1/PG III

1. Product Specification
2. Safety Data Sheet
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