4-[5-(4-bromophenyl)-3-(trifluoromethyl) pyrazol-1-yl]benzenesulfonamide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-Phenylsulfonamide-3-trifluoromethyl-5-parabromophenylpyrazole
Trifluoromethylated Building Blocks, PET Probe Building Blocks
KUMI3F195
170569-93-4

1396
10196156
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-[5-(4-bromophenyl)-3-(trifluoromethyl) pyrazol-1-yl]benzenesulfonamide
C16H11BrF3N3O2S
446.24
≥97%
White to Yellow Solid
60-65°C
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at room temperature
4-[5-(4-bromophenyl)-3-(trifluoromethyl) pyrazol-1-yl]benzenesulfonamide is a useful trifluoromethylated building block for the preparation of various pharmaceutical compounds of interest, such as PET probes of the COX-2 inhibitor.
Cyclooxygenase inhibitors - Current status and future prospects. [1]
Selective PGHS-2 Inhibitors: A Rational Approach for Treatment of the Inflammation. [2]
Synthesis of [11C]celecoxib: A potential PET probe for imaging COX-2 expression. [3]
Synthesis, anti-inflammatory evaluation and docking studies of some new fluorinated fused quinazolines. [4]
Efficient sequential synthesis of PET Probes of the COX-2 inhibitor [ 11C]celecoxib and its major metabolite [11C]SC-62807 and in vivo PET evaluation. [5]
References:
[1] G.Dannhardt, et al, Eur. J. Med. Chem., 2001, 36(2), pp 109-126.
[2] C.R.Rodrigues, et al, Curr. Med. Chem., 2002, 9(8), pp 849-867.
[3] J.Prabhakaran, et al, J. Label. Compd. Radiopharm., 2005, 48(12), pp 887-895.
[4] C.Balakumar, et al, Eur. J. Med. Chem., 2010, 45(11), pp 4904-4913.
[5] M.Takashima-Hirano, et al, Bioorg. Med. Chem., 2011, 19(9), pp 2997-3004.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not known hazard



NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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