4-bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-bromo-2-(2,2,2-trifluoro-1,1-dimethylethyl)pyridine
Trifluoromethyl Building Blocks
KUMI3F178
1357476-67-5
MFCD22393679
71682810
22219738
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
C9H9BrF3N
268.08
≥97%
White to Yellow Solid

5g,10g,25g,50g,100g,250g and 500g
Store at room temperature
4-bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine is a trifluoromethylated intermediate for the preparation of the Phosphatidylinositol-3-kinase α (PI3Kα) inhibitor, which is a therapeutic target of high interest in anticancer drug research.
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. [1]
Comparison of 19F NMR and 14C Measurements for the Assessment of ADME of BYL719 (Alpelisib) in Humans. [2]
References:
[1] P.Furet, et al, Bioorg. Med. Chem. Lett., 2013, 23(13), pp 3741-3748.
[2] A.D.James, et al, Drug Metab. Dispos., 2017, 45(8), pp 900-907.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a hazardous substance or mixture


2933399990
NONH for all modes of transport

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