4-hydroxy-3-(trifluoromethyl)benzonitrile is a useful trifluoromethylated building blocks for the synthesis of various pharmaceutical compounds, such as substituted naphthyridines for SYK kinase inhibitors, bicalutamide and enzalutamide derivatives as antiproliferative agents for prostate cancer treatment.
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. 
Efficient cross-coupling of aryl/alkenyl triflates with acyclic secondary alkylboronic acids. 
Synergistic Photo-Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides with Molecular Oxygen. 
 M.Bassetto, et al, Eur. J. Med. Chem., 2016, 118, pp 230-243.