4-hydroxy-3-(trifluoromethyl)benzonitrile

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
4-oxidanyl-3-(trifluoromethyl)benzenecarbonitrile
Trifluoromethyl Building Blocks
KUMI3F90
124811-71-8
MFCD06797882
11336547
18402325
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-hydroxy-3-(trifluoromethyl)benzonitrile
C8H4F3NO
187.12
≥98.0%
White Solid
174-175°C
5g,10g,25g,50g,100g,250g and 500g
Store at room temperature
4-hydroxy-3-(trifluoromethyl)benzonitrile is a useful trifluoromethylated building blocks for the synthesis of various pharmaceutical compounds, such as substituted naphthyridines for SYK kinase inhibitors, bicalutamide and enzalutamide derivatives as antiproliferative agents for prostate cancer treatment.
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. [1]
Efficient cross-coupling of aryl/alkenyl triflates with acyclic secondary alkylboronic acids. [2]
Synergistic Photo-Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides with Molecular Oxygen. [3]
References:
[1] M.Bassetto, et al, Eur. J. Med. Chem., 2016, 118, pp 230-243.
[2] T.Si, et al, Org. Biomol. Chem., 2017, 46(15), pp 9903-9909.
[3] X.Zhang, et al, Org. Lett., 2018, 20(3), pp 708-711.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H317,H319
P280,P305+P351+P338

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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