4-hydroxy-6-(trifluoromethyl)pyrimidine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
6-trifluoromethyl-4-hydroxypyrimidine, 6-(trifluoromethyl)pyrimidine-4-ol
Trifluoromethyl Building Blocks
KUMI3F88
1546-78-7
MFCD00192530
24864019
10062004
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-hydroxy-6-(trifluoromethyl)pyrimidine
C5H3F3N2O
164.09
≥99.0%(HPLC)
White to Yellow Crystalline Powder
169-171°C
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at room temperature
4-hydroxy-6-(trifluoromethyl)pyrimidine is a useful trifluoromethylated building block for the synthesis of various pharmaceutical pyrimidine-containing compounds, such as 10-[3-(6-trifluoromethyl-pyrimidin-4-yloxy)-propoxy]-(20S)-camptothecin and Brominated 4-(trifluoromethyl)pyrimidines, etc..
Brominated 4-(trifluoromethyl)pyrimidines: A convenient access to versatile intermediates. [1]
Metal-bearing and trifluoromethyl-substituted pyrimidines: Generation and functionalization. [2]
Synthesis and antitumor activity of novel 10-substituted camptothecin analogues. [3]
Synthesis and antitumor activity of novel 20s-camptothecin analogues. [4]
Cytotoxicity and Topo i targeting activity of substituted 10-nitrogenous heterocyclic aromatic group derivatives of SN-38. [5]
Novel pyrimidine associated thiazolidines: Design, synthesis, characterization and evaluation as antibacterial agents. [6]
References:
[1] L.Ondi, et al, Eur. J. Org. Chem., 2004, 17, pp 3714-3718.
[2] M.Schlosser, et al, Eur. J. Org. Chem., 2006, 6, pp 1593-1598.
[3] Q.Li, et al, Bioorg. Med. Chem., 2006, 14(21), pp 7175-7182.
[4] Q.Li, et al, Bioorg. Med. Chem. Lett., 2009, 19(2), pp 513-515.
[5] Q.Li, et al, Eur. J. Med. Chem., 2010, 45(7), pp 3200-3206.
[6] C.Maddireddi, et al, Asian J. Chem., 2017, 29(9), pp 1972-1976.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933.59.9500
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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