4-hydroxy-6-(trifluoromethyl)pyrimidine is a useful trifluoromethylated building block for the synthesis of various pharmaceutical pyrimidine-containing compounds, such as 10-[3-(6-trifluoromethyl-pyrimidin-4-yloxy)-propoxy]-(20S)-camptothecin and Brominated 4-(trifluoromethyl)pyrimidines, etc..
Brominated 4-(trifluoromethyl)pyrimidines: A convenient access to versatile intermediates. 
Metal-bearing and trifluoromethyl-substituted pyrimidines: Generation and functionalization. 
Synthesis and antitumor activity of novel 10-substituted camptothecin analogues. 
Synthesis and antitumor activity of novel 20s-camptothecin analogues. 
Cytotoxicity and Topo i targeting activity of substituted 10-nitrogenous heterocyclic aromatic group derivatives of SN-38. 
Novel pyrimidine associated thiazolidines: Design, synthesis, characterization and evaluation as antibacterial agents. 
 L.Ondi, et al, Eur. J. Org. Chem., 2004, 17, pp 3714-3718.
 M.Schlosser, et al, Eur. J. Org. Chem., 2006, 6, pp 1593-1598.