5,5,5-Trifluoro-4-oxopentanoic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5,5,5-Trifluorolevulinic acid
Trifluoromethylating Building Blocks
KUMI3F202
684-76-4
MFCD07779786
20543330
1909522
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5,5,5-Trifluoro-4-oxopentanoic acid
C5H5F3O3
170.09
≥95%
White to Pale yellow Solid
57-58°C
5g,10g,20g,50g,100g,200g and 500g
Store at room temperature
5,5,5-Trifluoro-4-oxopentanoic acid is a trifluoromethylated building block for the synthesis of various pharmaceutical compounds, such as 2′-trifluoromethyl analogue of indomethacin used as potent and selective COX-2 inhibitor.
Synthesis of indolizidine derivatives trifluoromethylated at bridgehead position via acyl iminium ion intermediates derived from ring-chain tautomerism of 5,5,5- trifluoro-4-oxopentanoyl arylethylamides. [1]
The 2′-trifluoromethyl analogue of indomethacin is a potent and selective COX-2 inhibitor. [2]
References:
[1] T.Okano, et al, Heterocycles, 1997, 44(1), pp 227-236.
[2] A.L.Blobaum. et al, ACS Med. Chem. Lett., 2013, 4(5), pp 486-490.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H317,H319
P280,P305+P351+P338
29181998
NONH for all modes of transport.

1. Product Specification
2. Safety Data Sheet
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