5-bromo-3-(trifluoromethyl)pyridin-2-amine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-amino-5-bromo-3-(trifluoromethyl)pyridine
Trifluoromethyl Building Blocks
KUMI3F109
79456-34-1
MFCD10758088
20525383
11440644
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-bromo-3-(trifluoromethyl)pyridin-2-amine
C6H4BrF3N2
241.01
≥95%
White to Light-brown Solid
66-75°C
5g,10g,25g,50g and 100g
Store at room temperature
5-bromo-3-(trifluoromethyl)pyridin-2-amine is an useful building block for the synthesis of various pharmaceutical compounds, e.g. Imidazopyridine inhibitors of PI3 kinases,which is a family of lipid kinases mediating numerous cell processes such as proliferation, migration and differentiation.
An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]. [1]
Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K. [2]
References:
[1] D.Zhang, et al, Chem. Commun., 2012, 48(23), pp 2909-2911.
[2] S.Pecchi, et al, Bioorg. Med. Chem. Lett., 2013, 23(16), pp 4652-4656.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H319
P305+P351+P338
2933399990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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