5-Hydroxy-5-(trifluoromethyl)oxolan-2-one

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-hydroxy-5-(trifluoromethyl)dihydrofuran-2(3H)-one
Trifluoromethylating Building Blocks
KUMI3F203
117192-54-8

14004265
4179701
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-Hydroxy-5-(trifluoromethyl)oxolan-2-one
C5H5F3O3
170.09
≥95%
Colorless to Pale yellow Liquid

5g,10g,20g,50g,100g,200g and 500g
Store at room temperature
5-Hydroxy-5-(trifluoromethyl)oxolan-2-one is a trifluoromethylated building block for the preparation of various compounds in organic synthesis.
Synthesis of indolizidine derivatives trifluoromethylated at bridgehead position via acyl iminium ion intermediates derived from ring-chain tautomerism of 5,5,5- trifluoro-4-oxopentanoyl arylethylamides. [1]
Nucleophilic trifluoromethylation of anhydrides employing (trifluoromethyl)trimethylsilane: Synthesis of γ-trifluoromethylated γ-butyrolactones. [2]
References:
[1] T.Okano, et al, Heterocycles, 1997, 44(1), pp 227-236.
[2] C.Masusai, et al, J. F. Chem., 2013, 154, pp 37-42.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H317,H319
P280,P305+P351+P338

NONH for all modes of transport.

1. Product Specification
2. Safety Data Sheet
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