5-TFA-ap-dU phosphoramidite

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN

Trifluorinated Building Blocks, Linkers for Gene(DNA) Sequencing
KUMI3F169
120016-98-0


5225267
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
5-TFA-ap-dU phosphoramidite
C44H49F3N5O9P
879.87
≥98%(HPLC)
White to yellow Solid

5g,10g,25g,50g,100g,200g and 500g
Store at -20°C temperature
5-(3-trifluoroacetamidopropargyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine-3'-[(2-cyano-ethyl)-N,N-diisopropylaminophosphoramidite] (also named as 5-TFA-ap-dU phosphoramidite) is a trifluoromethyl-modified linker used for gene(DNA) sequencing and mapping.
Oligonucleotide labelling: A concise synthesis of a modified thymidine phosphoramidite. [1]
Application of a Highly Robust and Efficient Fluorescence‐Resonance‐Energy‐Transfer (FRET) System in DNA. [2]
Functionalization of Mono‐ and Oligonucleotides with Phosphane Ligands by Amide Bond Formation. [3]
Accurate distance determination of nucleic acids via Förster resonance energy transfer: implications of dye linker length and rigidity. [4]
References:
[1] K.A.Cruickshank, et al, Tetrahedron Lett., 1988, 29(41), pp 5521-5524.
[2] L.Clima, et al, Helvetica, 2007, 90(6), pp 1082-1098.
[3] M.Nuzzolo, et al, Eur. J. Org. Chem., 2010, 17, pp 3229-3236.
[4] S.Sindbert, et al, J. Am. Chem. Soc., 2011, 33(8), pp 2463-2480.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a dangerous goods



NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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