5-(trifluoromethyl)thiophene-2-carboxylic acid is an important building block for the synthesis of various trifluoromethyl-substituted organic compounds in pharmaceuticals, agrochemicals and material sciences, e.g. substituted 1,2,3-triazoles as NR2B receptor ligands for the treatment of disease states, disorders, and conditions mediated by NR2B receptor activity; positive allosteric modulators of α7 nAChRs for the treatment of disorders; Triazinone compound as T-type calcium channel inhibitor for the treatment of pain;Pesticidal pyrimidine in controlling pests such as insects and other invertebrates, etc..
Synthesis and polymerization of ethynylthiophenes and ethynylfurans containing trifluoromethyl groups. 
 M.Nishida, et al, J. F. Chem., 1990, 46(3), pp 445-459.