6-(trifluoromethyl)pyridine-2-carboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
6-(trifluoromethyl)picolinic acid
Trifluoromethylated Building Blocks
KUMI3F198
131747-42-7
MFCD02180819
14761453
4249254
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
6-(trifluoromethyl)pyridine-2-carboxylic acid
C7H4F3NO2
191.11
≥97%
White to Beige Solid
154-158°C
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at room temperature
6-(trifluoromethyl)pyridine-2-carboxylic acid (also named as 6-(trifluoromethyl)picolinic acid) is a useful trifluoromethylated building block for the preparation of various compounds of interest in pharmaceuticals and agrochemicals.
A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin. [1]
SAR studies of non-zinc-chelating MMP-13 inhibitors: Improving selectivity and metabolic stability. [2]
From Lead to Drug Candidate: Optimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as Agents for the Treatment of Triple Negative Breast Cancer. [3]
Discovery of N-(3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4-methylphenyl)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs). [4]
References:
[1] J.P.Kennedy, et al, Bioorg. Med. Chem. Lett., 2009, 19(2), pp 3204-3208.
[2] D.A.Gao, et al, Bioorg. Med. Chem. Lett., 2010, 20(7), pp 5039-5043.
[3] C.H.Zhang, et al, J. Med. Chem., 2016, 59(21), pp 9788-9805.
[4] Q.Wang, et al, J Med. Chem., 2016, 59(8), pp 3964-3979.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P305+P351+P338
2933399990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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