Diethyl 2-(2,2,2-trifluoroacetyl)butanedioate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Diethyl 2-(2,2,2-trifluoroacetyl)succinate
Trifluoromethylating Building Blocks
KUMI3F201
94633-25-7
MFCD07779768
11346247
1884365
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Diethyl 2-(2,2,2-trifluoroacetyl)butanedioate
C10H13F3O5
270.20
≥95%
Colorless to Pale yellow Liquid
221-288°C
5g,10g,20g,50g,100g,200g and 500g
Store at room temperature
Diethyl 2-(2,2,2-trifluoroacetyl)butanedioate is a trifluoromethylated building block for the synthesis of various pharmaceutical compounds, such as Angiotensin II Antagonists and COX-2 inhibitors.
Concise synthesis of ω-fluoroalkylated ketoesters. A building block for the synthesis of six-, seven-, and eight-membered fluoroalkyl substituted 1,2-diaza-3-one heterocycles. [1]
The 2′-trifluoromethyl analogue of indomethacin is a potent and selective COX-2 inhibitor. [2]
References:
[1] W.Wan, et al, Tetrahedron, 2009, 65(21), pp 4212-4219.
[2] A.L.Blobaum. et al, ACS Med. Chem. Lett., 2013, 4(5), pp 486-490.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H317,H319
P280,P305+P351+P338
29181998
NONH for all modes of transport.

1. Product Specification
2. Safety Data Sheet
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