Ethyl 5,5,5-trifluoro-4-oxopentanoate (also named as 4-Trifluoromethyl-4-oxobutyric acid ethyl ester)is a trifluoromethylated building block for the synthesis of various compounds in pharmaceuticals and agrochemicals, such as synthesis of coumarin-based anticoagulates, antiiflammatory agents and antioxidation superoxide scavengers, and preparation of acylated amine compounds for fungicidal agents.
Concise synthesis of ω-fluoroalkylated ketoesters. A building block for the synthesis of six-, seven-, and eight-membered fluoroalkyl substituted 1,2-diaza-3-one heterocycles. 
Analysis of fragmentations of coumarins in mass spectrometry using the electronic charges of atoms. 
 W.Wan, et al, Tetrahedron, 2009, 65(21), pp 4212-4219.