Pyridinium trifluoromethanesulfonate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3,3,3-Trifluoro-2,2-dimethylpropionic acid methyl ester
Trifluoromethyl Building Blocks
KUMI3F177
52193-54-1
MFCD18253569
53485768
22315445
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Methyl 3,3,3-trifluoro-2,2-dimethylpropanoate
C6H9F3O2
170.13
≥98%
Colorless to Yellow Liquid

5g,10g,25g,50g,100g,250g and 500g
Store at room temperature
Methyl 3,3,3-trifluoro-2,2-dimethylpropanoate is a trifluoromethlated pharmaceutical intermediate, for instance, in the preparation of RET Kinase inhibitor as a clinical candidate to treat IBS disease.
Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E. [1]
Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS. [2]
References:
[1] M.W.Rowbotton, et al, J. Med. Chem., 2015, 55(3), pp 1082-1105.
[2] H.Schenck Eidam, et al, ACS Med. Chem. Lett., 2018, 9(7), pp 623-628.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H302,H312,H315,H319,H332,H335
P261,P280,P305+P351+P338

UN 1993 3/PG III

1. Product Specification
2. Safety Data Sheet
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