Methyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-(Methoxycarbonyl)-5-(trifluoromethyl)-1H-pyrrole
Trifluoromethyl Building Blocks
KUMI3F98
952182-25-1
MFCD09841653
45073280
22440710
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Methyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate
C7H6F3NO2
193.12
≥98%
White Solid
95-97°C
5g,10g,25g,50g,100g,250g and 500g
Store at room temperature
Methyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate is an important building block for the synthesis of numerous trifluoromethylated heterocycles widely applied in pharmaceuticals, agrochemicals and material sciences.
Trifluoromethylation of heterocycles via visible light photoredox catalysis. [1]
Rapid Trifluoromethylation and Perfluoroalkylation of Five‐Membered Heterocycles by Photoredox Catalysis in Continuous Flow. [2]
Metal-Free Photocatalytic Radical Trifluoromethylation Utilizing Methylene Blue and Visible Light Irradiation. [3]
Mechanisms and applications of cyclometalated Pt(II) complexes in photoredox catalytic trifluoromethylation. [4]
Graphitic Carbon Nitride Polymer as a Recyclable Photoredox Catalyst for Fluoroalkylation of Arenes. [5]
Continuous Flow Homolytic Aromatic Substitution with Electrophilic Radicals: A Fast and Scalable Protocol for Trifluoromethylation. [6]
References:
[1] N.Iqbal, et al, Tetrahedron Lett., 2012, 53(15), pp 2005-2008.
[2] N.J.W.Straathof, et al, ChemSusChem, 2014, 7(16), pp 1612-1617.
[3] S.P.Pitre, et al, ACS Catal., 2014, 4(8), pp 2530-2535.
[4] W.J.Choi, et al, Chem. Sci., 2015, 6(2), pp 1454-1464.
[5] M.Baar. et al, Chem. Eur. J., 2015, 21(2), pp 526-530.
[6] J.L.Monteiro, et al, Chem. Eur. J., 2017, 23(1), pp 176-186.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319.H335
P264,P280,P305+P351+P338
2933998090
NONH for all modes of transport

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