2,2,2-trifluoro-N-methyl-N-[(1R,2S)-1-phenyl-1-trimethylsilyloxypropan-2-yl]acetamide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
N-trifluoroacetyl-O-trimethylsilylephedrine
Trifluoromethyl Reagents
KUMI3F91
497937-77-6
 
11336547
9568188
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2,2,2-trifluoro-N-methyl-N-[(1R,2S)-1-phenyl-1-trimethylsilyloxypropan-2-yl]acetamide
C15H22F3NO2Si
333.43
≥98.0%(HPLC)
Colorless to Light-yellow Solid
51-52°C
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at room temperature
N-trifluoroacetyl-O-trimethylsilylephedrine is a newly-developed and promising chiral reagents for nucleophilic and entantioselective trifluoromethylation of  a broad range of non-enolizable and enolizable carbonyl compounds(aldehydes, ketones, α,β-unsaturated) in satisfying yields under mild conditions. Although it is a chiral reagent, it doesn't induce any chirality in the trifluoromethylation of prochiral carbonyl substrates,without yielding enantiomeric excess.
Trifluoroacetamides from amino alcohols as nucleophilic trifluoromethylating reagents. [1]
Towards enantioselective nucleophilic trifluoromethylation. [2]
References:
[1] J.Joubert, et al, Angew. Chem. Int. Ed., 2003, 42(27), pp 3133-3136.
[2] S.Roussel, et al, Chem. Eur. J., 2005, 11(3), pp 939-944.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P305+P351+P338
2924190090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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