Trifluoromethanesulfonic acid 

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Triflic acid,TFMS,TFSA,HOTf,TfOH
Trifluoromethylating Reagents, Deglycosylation agents 
KUMI3F209
1493-13-6
MFCD00007514
62406
1812100
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Trifluoromethanesulfonic acid 
CHF3O3S
150.07
≥99%
Colorless to Light yellow Liquid
162°C
50g,100g,250g,500g,1kg,5kg,25kg and 50kg
Store at room temperature
Trifluoromethanesulfonic acid (also named as Triflic acid,TFMS,TFSA,HOTf,TfOH) is the strongest organic acid, which is mainly used as a catalyst for esterification and deglycosylation for glycoproteins. It is known as a versatile synthetic toolkit for the preparation of various compounds of interest in medicine and chemical industry, such as nucleoside, antibiotics, steroid, glycoside, synthetic vitamin and the modification of silicone rubber, etc..
Trifluoromethanesulfonic Acid, an Unusually Powerful Catalyst for the Michael Addition Reaction of β-Ketoesters under Solvent-Free Conditions. [1]
Trifluoromethanesulfonic Acid Catalyzed Novel Friedel–Crafts Acylation of Aromatics with Methyl Benzoate. [2]
Addition reaction of dialkyl disulfides to terminal alkynes catalyzed by a rhodium complex and trifluoromethanesulfonic acid. [3]
Versatile synthesis of 3, 4-dihydroisoquinolin-1 (2H)-one derivatives via intra-molecular Friedel-Crafts reaction with trifluoromethanesulfonic acid. [4]
One-pot preparation of 2, 5-disubstituted and 2, 4, 5-trisubstituted oxazoles from aromatic ketones with molecular iodine, oxone, and trifluoromethanesulfonic acid in nitriles. [5]
References:
[1] H.Kotsuki, et al, J. Org. Chem., 1999, 64(10), pp 3770-3773.
[2] J.P.Hwang, et al, Tetrahedron, 2000, 56(37), pp 7199-7203.
[3] M.Arisawa, et al, Org. Lett., 2001, 3(5), pp 763-764.
[4] R.Murashige, et al, Tetrahedron Lett., 2015, 56(23), pp 3410-3412.
[5] S.Imai, Tetrahedron, 2015, 71(33), pp 5267-5274.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H302+H312,H314
P280,P305+P351+P338,P310
2904990090
UN 3265 8/PG II

1. Product Specification
2. Safety Data Sheet
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