Trimethylsilyl trifluoromethanesulfonate 

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
TMS triflate,TMSOTf,Trifluoromethanesulfonic acid trimethylsilylester 
Trimethylsilylating Reagents, Acid Catalysts
KUMI3F210
27607-77-8
MFCD00000406
65367
1868911
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Trimethylsilyl trifluoromethanesulfonate
C4H9F3O3SSi
222.25
≥99%
Colorless Liquid
77°C/80mmHg
50g,100g,250g,500g,1kg,5kg,25kg and 50kg
Store at room temperature
Trimethylsilyl trifluoromethanesulfonate (also named as TMS triflate,TMSOTf) is an efficient trimethylsilylating reagent and strong lewis acid catalst widely used in organic synthesis.
Trimethysilyl triflate in organic synthesis. [1]
Trimethylsilyl trifluoromethanesulfonate as an effective catalyst for glycoside synthesis. [2]
An extremely fast and efficient acylation reaction of alcohols with acid anhydrides in the presence of trimethylsilyl trifluoromethanesulfonate as catalyst. [3]
An Extremely Powerful Acylation Reaction of Alcohols with Acid Anhydrides Catalyzed by Trimethylsilyl Trifluoromethanesulfonate. [4]
Synthesis of homoallyl ethers via allylation of acetals in ionic liquids catalyzed by trimethylsilyl trifluoromethanesulfonate. [5]
Protection for the Hydroxyl Group, Including 1,2‐ and 1,3‐Diols. [6]
References:
[1] R.Noyori, et al, Tetrahedron, 1981, 37(23), pp 3899-3910.
[2] T.Ogawa, et al, Carbonhydr. Res., 1981, 93(1), pp C6-C9.
[3] P.A.Procopiou, et al, Chem. Commun., 1996, 0(23), pp 2625-2626.
[4] P.A.Procopiou, et al, J. Org. Chem., 1998, 63(7), pp 2342-2347.
[5] H.M.Zerth, et al, Org. Lett., 2003, 5(1), pp 55-57.
[6] P.G.M. Wuts, et al, Greene's Protective Groups in Organic Synthesis, 5th, ed., 2014, Chap. 2, 17.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H226,H314
P280,P305+P351+P338,P310
2931900090
UN 2920 3(8)/PG II

1. Product Specification
2. Safety Data Sheet
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