2',3'-Dideoxyguanosine (also known as ddG, ddGuo,DoG) is a nucleoside analog of deoxyguanosine typically used for the preparation of nucleoside analogue drugs with anti-HBV activity. e.g. Metacavir (6-O-methyl-2′, 3′-dideoxyguanosine) is a reverse transcriptase inhibitor with potent activity against hepatitis B virus (HBV), it is a prodrug that is activated in vivo by demethylation and conversion to 2′, 3′-dideoxyguanosine.
Antiviral guanosine analogs as substrates for deoxyguanosine kinase: Implications for chemotherapy.
In Vitro Anti-hepatitis B Virus Activity of 2′,3′-Dideoxyguanosine.