2',3'-Dideoxyguanosine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
ddG, ddGuo, DoG
Bridge to Biologics, Modified Nucleosides
KUMI0F511
85326-06-3
MFCD00057074
135463029
4263314
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2',3'-Dideoxyguanosine
C10H13N5O3
251.24
≥98%
White to Off-White Solid
260°C
5g,10g,25g,100g,250g,500g and 1kg
Store at room temperature
  2',3'-Dideoxyguanosine (also known as ddG, ddGuo,DoG) is a nucleoside analog of deoxyguanosine typically used for the preparation of  nucleoside analogue drugs with anti-HBV activity.  e.g. Metacavir (6-O-methyl-2′, 3′-dideoxyguanosine) is a reverse transcriptase inhibitor with potent activity against hepatitis B virus (HBV), it is a prodrug that is activated in vivo by demethylation and conversion to 2′, 3′-dideoxyguanosine.
  Antiviral guanosine analogs as substrates for deoxyguanosine kinase: Implications for chemotherapy. [1]
  In Vitro Anti-hepatitis B Virus Activity of 2′,3′-Dideoxyguanosine. [2]
References:
[1] A.Herrstrom Sjoberg, et al, Antimicrob. Agents Chemother., 2001, 45(3), pp 719-742.
[2] P.Zhang, et al, Virol. Sin., 2018, 33(6), pp 538-544.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a hazardous substance or mixture
 
 
2934999090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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