2',3'-Dideoxyuridine (also known as ddU) is a nucleoside analog of deoxyuridine typically used as prodrug or precursor in antisense oligonucleotide synthes and in the preparation of ProTide derivatives against HIV-1 and HIV-2.
Design, synthesis, and anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U), 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.[1]
Biotransformation of 2,6‐diaminopurine nucleosides by immobilized Geobacillus stearothermophilus.[2]