3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3',5'-TIPS-adenosine, 3',5'-TIPS-rA
Bridge to Biologics, Nucleosides & Modified Nucleosides
KUMI0F655
69304-45-6
MFCD00012186
9983798
1233156
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine
C22H39N5O5Si2
509.75
≥98%
White to Off-white Solid
143-145°C
5g,10g,50g,100g,250g,500g and 1kg
Store at 2-8°C temp.
 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine (also known as 3',5'-TIPS-adenosine, 3',5'-TIPS-rA) is a modified nucleoside of adenosine typically used in the preparation of DNA and RNA duplexes with exonic splicing enhancer activity.
Synthesis of 2′-O-[2-(N-Methylcarbamoyl)ethyl]ribonucleosides Using Oxa-Michael Reaction and Chemical and Biological Properties of Oligonucleotide Derivatives Incorporating These Modified Ribonucleosides. [1]
Poly(ADP-Ribose) - A unique natural polymer structural features, biological role and approaches to the chemical synthesis. [2]
References:
[1] T.Yamada, et al, J. Org. Chem., 2011, 76(9), pp 3042-3053.
[2] M.S.Drenichev, et al, Nucleos. Nucleot. Nucl., 2015, 34(4), pp 258-276.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated as a hazardous substance or mixture


2940000080
NONH for all modes of transport

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