5-Iodo-2'-Deoxyuridine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN 3582735
5-Iododesoxyuridine, 5-I-dU,5-IUdR, IDU, IdUrd
Bridge to Biologics, Modified Nucleosides, Gene Sequencing Reagents
KUMI0F530
54-42-2
MFCD00134656
5905
30397
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-Iodo-2'-Deoxyuridine
C9H11IN2O5
354.10
≥98%
White to Off-white Solid
194-195°C
5g,10g,50g,100g,500g and 1kg
Store at 2-8°C temp.
 5-Iodo-2'-Deoxyuridine (also named as 5-I-dU,5-IUdR, IDU, IdUrd) is a pyrimidine analog (halogenated thymidine) that has antiviral activity agains vaccinia virus (orthopoxviruses). It is typcially used as a radiosensitizer in human cancer studies and a reagent in gene sequencing.
 Effect of 5-iodo-2′-deoxyuridine on vaccinia virus (orthopoxvirus) infections in mice. [1]
 Turning Off Transcription with Bacterial RNA Polymerase through CuAAC Click Reactions of DNA Containing 5-Ethynyluracil. [2]
Propargylamine-selective dual fluorescence turn-on method for post-synthetic labeling of DNA. [3]
Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis. [4]
 References:
[1] J.Neytes, et al, Antimicrob. Agents Chemother., 2002, 46(9), pp 2842-2847.
[2] M.Slavickova, et al, Chemistry, 2018, 24(33), pp 8311-8314.
[3] N.Van Thang, et al, Chem. Commun., 2020, 56(21), 3199-3202.
[4] Y.Qian, et al, Eur. J. Med. Chem., 2020, 187, art. no. 111948.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated
 
 
29349990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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