1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-Oxide Hexafluorophosphate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN 3582735
HBTU
Bridge to Biologics, Coupling Reagents
KUMI6F99
94790-37-1
MFCD00075445
2733084
4650356
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-Oxide Hexafluorophosphate
C11H16F6N5OP
379.24
≥98%
White to Off-white Solid
200°C
5g,10g,50g,100g,500g, 1kg and 25kg
Store at 2-8°C temp.
 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-Oxide Hexafluorophosphate (also named as HBTU) is commonly used as as a coupling reagent for solid-phase peptide synthesis. It has been shown to effectively suppress racemization.
 Structural studies of reagents for peptide bond formation: Crystal and molecular structures of HBTU and HATU. [1]
 Total synthesis of cyclodepsipeptide spiruchostatin A on silyl-linked polymer-support. [2]
 Fluorenylmethoxycarbonyl-Protected O-Glycosyl-N-methyl Amino Acids: Building Blocks for the Synthesis of Conformationally Tuned Glycopeptide Antigens. [3]
 References:
[1] I.Abdelmoty, et al, Lett. Pept. Sci., 1994, 1(2), pp 56-67.
[2] M.Yoshida, et al, Tetradron, 2015, 71(40), pp 7647-7653..
[3] A.E.Buba, et al, Eur. J. Org. Chem., 2015, 2015(26), pp 5764-5774.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated
 

29339980
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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