Pomalidomide-PEG3-C2-NH2

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN 3582735
Cereblon Ligand-Linker Conjugates 5, E3 ligase Ligand-Linker Conjugates 30
Bridge to Biologics, Precursor for PROTACs
KUMI0F406
2093416-31-8
 
131999703
31621676
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Pomalidomide-PEG3-C2-NH2
C21H28N4O7
448.47
≥98%
White to Off-White Solid
 
5g,10g,50g,100g,500g and 1kg
Store at 2-8°C temp.
  Pomalidomide-PEG3-C2-NH2 (also known as Cereblon Ligand-Linker Conjugates 5, E3 ligase Ligand-Linker Conjugates 30) is typically used as a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker for the synthesis of proteolysis-targeting chimera (PROTAC) technologies.
 Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. [1]
 
Development of a PDEδ-Targeting PROTACs that Impair Lipid Metabolism. [2]
 References:
[1] Y.Li, et al, J. Med. Chem., 2019, 62(2), pp 448-466.
[2] M.Winzker, et al, Angew. Chem. Intl. Ed. Engl., 2020, 59(14), pp 5595-5601.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated
 
 
29339900
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.